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Discovery of 7-Methyl-5-(1-[3-(Trifluoromethyl)Phenyl]Acetyl-2,3-Dihydro-1h-Indol-5-Yl)-7h-Pyrrolo[2,3-D]Pyrimidin-4-Amine (Gsk2606414), a potent and selective first-in-Class inhibitor of protein kinase r (Pkr)-like endoplasmic reticulum kinase (Perk)

Accordingly, Nasca and coworkers found that chronic unpredictable stress causes large reductions in hippocampal mGlu2 receptors exclusively in mice that are not resilient to stress, and that mice lacking mGlu2 receptors are more susceptible to stress [138]

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10.3390/ijms22073603 33 GabbyM.TauberM.PoratS.SimantovR